Pii: 0141-5425(92)90058-s

نویسنده

  • E. D. Lehmann
چکیده

A clinical model ofglucose-insulin interaction in insulin-dependent diabetes mellitus has been developedforpatient and medical staff education. The model attempts to reflect the underlying (pathojphysiology of insulin action and carbohydrate absorption in quantitative terms such as insulin sensitivity, volume ofglucose and insulin distribution and maximal rate ofgastric emptying. The model's predictions also allow a 24 h simulation ofpatient bloodglucoseprofiles to be generated. A description of the model is provided and its operation illustrated by clinical case studies of insulintreated diabetic patients. The possible use of the model as a tool for automated insulin dosage adjustment is explored.

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تاریخ انتشار 2003